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1

Cocrystal Solubility Product Prediction Using an in combo Model and Simulations to Improve Design of Experiments

Journal:

Pharmaceutical Research

Year:

2018

Language:

english

File:

PDF, 7.99 MB

english, 2018

2

Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

Fagerberg, Jonas H., Tsinman, Oksana, Sun, Na, Tsinman, Konstantin, Avdeef, Alex, Bergström, Christel A. S.

Journal:

Molecular Pharmaceutics

Year:

2010

Language:

english

File:

PDF, 3.24 MB

english, 2010

3

Absorption and Drug Development (Solubility, Permeability, and Charge State) || Permeability-PAMPA

Year:

2012

Language:

english

File:

PDF, 1.94 MB

english, 2012

4

The rise of PAMPA

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2005

Language:

english

File:

PDF, 917 KB

english, 2005

5

A PAMPA Study of the Permeability-Enhancing Effect of New Ceramide Analogues

Bálint Sinkó, József Kökösi, Alex Avdeef, Krisztina Takács-Novák

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 190 KB

english, 2009

6

Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine

Giulia Caron, Giuseppe Ermondi, Alessandro Damiano, Laura Novaroli, Oksana Tsinman, Jeffrey A. Ruell, Alex Avdeef

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 548 KB

english, 2004

7

Coexistence of passive and carrier-mediated processes in drug transport

Sugano, Kiyohiko, Kansy, Manfred, Artursson, Per, Avdeef, Alex, Bendels, Stefanie, Di, Li, Ecker, Gerhard F., Faller, Bernard, Fischer, Holger, Gerebtzoff, Grégori

Journal:

Nature Reviews Drug Discovery

Year:

2010

Language:

english

File:

PDF, 599 KB

english, 2010

8

pH-Metric Solubility. 2: Correlation Between the Acid-Base Titration and the Saturation Shake-Flask Solubility-pH Methods

Alex Avdeef, Cynthia M. Berger, Charles Brownell

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 299 KB

english, 2000

9

pH-Metric log P. Part 1. Difference Plots for Determining Ion-Pair Octanol-Water Partition Coefficients of Multiprotic Substances

Journal:

Molecular Informatics

Year:

1992

Language:

english

File:

PDF, 559 KB

english, 1992

10

Solubility of sparingly-soluble ionizable drugs

Journal:

Advanced Drug Delivery Reviews

Year:

2007

Language:

english

File:

PDF, 2.27 MB

english, 2007

11

PAMPA—a drug absorption in vitro model: 5. Unstirred water layer in iso-pH mapping assays and pKaflux—optimized design (pOD-PAMPA)

Jeffrey A Ruell, Konstantin L Tsinman, Alex Avdeef

Journal:

European Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 239 KB

english, 2003

12

PAMPA—a drug absorption in vitro model: 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones

Marival Bermejo, Alex Avdeef, Ana Ruiz, Ricardo Nalda, Jeffrey A. Ruell, Oksana Tsinman, Isabel González, Carlos Fernández, Gloria Sánchez, Teresa M. Garrigues, Virginia Merino

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 288 KB

english, 2004

13

Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA method

Alex Avdeef, Per Artursson, Sibylle Neuhoff, Lucia Lazorova, Johan Gråsjö, Staffan Tavelin

Journal:

European Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 413 KB

english, 2005

14

Octanol−, Chloroform−, and Propylene Glycol Dipelargonat−Water Partitioning of Morphine-6-glucuronide and Other Related Opiates †

Avdeef, Alex, Barrett, David A., Shaw, P. Nicholas, Knaggs, Roger D., Davis, Stanley S.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 162 KB

english, 1996

15

Absorption and Drug Development (Solubility, Permeability, and Charge State) || Permeability: Blood-Brain Barrier

Year:

2012

Language:

english

File:

PDF, 757 KB

english, 2012

16

The Permeation of Amphoteric Drugs through Artificial Membranes − An in Combo Absorption Model Based on Paracellular and Transmembrane Permeability †

Tam, Kin Y., Avdeef, Alex, Tsinman, Oksana, Sun, Na

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.10 MB

english, 2010

17

Bjerrum plots for the determination of systematic concentration errors in titration data

Avdeef, Alex., Kearney, Diane L., Brown, Jessica A., Chemotti, Alfred R.

Journal:

Analytical Chemistry

Year:

1982

Language:

english

File:

PDF, 630 KB

english, 1982

18

Phosphate Precipitates and Water-Soluble Aggregates in Re-analyzed Solubility-pH Data of Twenty-five Basic Drugs

Journal:

Year:

2014

Language:

english

File:

PDF, 1.21 MB

english, 2014

19

Cocrystal solubility product analysis – Dual concentration-pH mass action model not dependent on explicit solubility equations

Journal:

European Journal of Pharmaceutical Sciences

Year:

2017

Language:

english

File:

PDF, 2.14 MB

english, 2017

20

Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database

Journal:

Year:

2020

File:

PDF, 3.21 MB

2020

21

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li, Artursson, Per, Avdeef, Alex, Benet, Leslie, Houston, Brian, Kansy, Manfred, Kerns, Edward, LennernÃ¤s, Hans, Smith, Dennis, Sugano, Kiyohiko

Journal:

Year:

2020

File:

PDF, 1.27 MB

2020

22

Structure-Lipophilicity Relationships of Neutral and Protonated β-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems

Giulia Caron, Guillaume Steyaert, Alessandra Pagliara, Frédéric Reymond, Patrizia Crivori, Patrick Gaillard, Pierre-Alain Carrupt, Alex Avdeef, John Comer, Karl J. Box, Hubert H. Girault, Bernard Test

Journal:

Helvetica Chimica Acta

Year:

1999

Language:

english

File:

PDF, 144 KB

english, 1999

23

Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

Alex Avdeef, Konstantin Tsinman, Oksana Tsinman, Na Sun, Dmytro Voloboy

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 389 KB

english, 2009

24

ChemInform Abstract: Estimating the Water Solubilities of Crystalline Compounds from Their Chemical Structures Alone.

James W. McFarland, Alex Avdeef, Cynthia M. Berger, Oleg A. Raevsky

Journal:

Year:

2001

File:

PDF, 25 KB

2001

25

Classification structure–activity relations (C-SAR) in prediction of human intestinal absorption

Donatas Zmuidinavicius, Remigijus Didziapetris, Pranas Japertas, Alex Avdeef, Alanas Petrauskas

Journal:

Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 225 KB

english, 2003

26

PAMPA—critical factors for better predictions of absorption

Alex Avdeef, Stefanie Bendels, Li Di, Bernard Faller, Manfred Kansy, Kiyohiko Sugano, Yukinori Yamauchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 1.10 MB

english, 2007

27

pH-metric log P. II: Refinement of partition coefficients and lonization constants of multiprotic substances

Journal:

Journal of Pharmaceutical Sciences

Year:

1993

Language:

english

File:

PDF, 892 KB

english, 1993

28

Ph-metric log P. 4. Comparison of partition coefficients determined by HPLC and potentiometric methods to literature values

Bryan Slater, Ann McCormack, Alex Avdeef, John E. A. Comer

Journal:

Journal of Pharmaceutical Sciences

Year:

1994

Language:

english

File:

PDF, 437 KB

english, 1994

29

pH–metric log P. 6. Effects of sodium, potassium, and N-CH3-D-glucamine on the Octanol–Water partitioning of prostaglandins E1 and E2

Alex Avdeef, Karl J. Box, Krisztina Takács-Novák

Journal:

Journal of Pharmaceutical Sciences

Year:

1995

Language:

english

File:

PDF, 833 KB

english, 1995

30

Determination of protonation macro- and microconstants and octanol/water partition coefficient of the antiinflammatory drug niflumic acid

Krisztina Takács-Novák, Alex Avdeef, Karl J. Box, Benjamin Podányi, György Szász

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

1994

Language:

english

File:

PDF, 791 KB

english, 1994

31

Biorelevant pKa (37 °C) predicted from the 2D structure of the molecule and its pKa at 25 °C

Na Sun, Alex Avdeef

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2011

Language:

english

File:

PDF, 701 KB

english, 2011

32

Weighting scheme for regression analysis using pH data from acid—base titrations

Journal:

Analytica Chimica Acta

Year:

1983

Language:

english

File:

PDF, 502 KB

english, 1983

33

Cadmium binding by biological ligands. 2 [1]. Formation of protonated and polynuclear complexes between cadmium and 2-mercaptoethylamine

Alex Avdeef, Jessica A. Brown

Journal:

Inorganica Chimica Acta

Year:

1984

Language:

english

File:

PDF, 720 KB

english, 1984

34

Potentiometric pKa determination of water-insoluble compounds: validation study in methanol/water mixtures

Krisztina Takács-Novák, Karl J. Box, Alex Avdeef

Journal:

International Journal of Pharmaceutics

Year:

1997

Language:

english

File:

PDF, 404 KB

english, 1997

35

PAMPA–Excipient Classification Gradient Map

Stefanie Bendels, Oksana Tsinman, Björn Wagner, Dana Lipp, Isabelle Parrilla, Manfred Kansy, Alex Avdeef

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 699 KB

english, 2006

36

Solubility-Excipient Classification Gradient Maps

Alex Avdeef, Stefanie Bendels, Oksana Tsinman, Konstantin Tsinman, Manfred Kansy

Journal:

Pharmaceutical Research

Year:

2007

Language:

english

File:

PDF, 887 KB

english, 2007

37

Miniaturized Rotating Disk Intrinsic Dissolution Rate Measurement: Effects of Buffer Capacity in Comparisons to Traditional Wood’s Apparatus

Alex Avdeef, Oksana Tsinman

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 640 KB

english, 2008

38

Leakiness and Size Exclusion of Paracellular Channels in Cultured Epithelial Cell Monolayers–Interlaboratory Comparison

Journal:

Pharmaceutical Research

Year:

2010

Language:

english

File:

PDF, 370 KB

english, 2010

39

Powder Dissolution Method for Estimating Rotating Disk Intrinsic Dissolution Rates of Low Solubility Drugs

Konstantin Tsinman, Alex Avdeef, Oksana Tsinman, Dmytro Voloboy

Journal:

Pharmaceutical Research

Year:

2009

Language:

english

File:

PDF, 240 KB

english, 2009

40

Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion—Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model

Oksana Tsinman, Konstantin Tsinman, Na Sun, Alex Avdeef

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 1004 KB

english, 2011

41

A NewIn SituBrain Perfusion Flow Correction Method for Lipophilic Drugs Based on the pH-Dependent Crone-Renkin Equation

Alex Avdeef, Na Sun

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 415 KB

english, 2011

42

In VitroPermeability of Poorly Aqueous Soluble Compounds Using Different Solubilizers in the PAMPA Assay with Liquid Chromatography/Mass Spectrometry Detection

Hanlan Liu, Chantel Sabus, Guy T. Carter, Chao Du, Alex Avdeef, Mark Tischler

Journal:

Pharmaceutical Research

Year:

2003

Language:

english

File:

PDF, 134 KB

english, 2003

43

Membrane–Water partitioning, membrane permeability, and baseline toxicity of the parasiticides ivermectin, albendazole, and morantel

Beate I. Escher, Cindy Berger, Nadine Bramaz, Jung-Hwan Kwon, Manuela Richter, Oksana Tsinman, Alex Avdeef

Journal:

Environmental Toxicology and Chemistry

Year:

2008

Language:

english

File:

PDF, 148 KB

english, 2008

44

PAMPA—a drug absorption in vitro model: 8. Apparent filter porosity and the unstirred water layer

Per E. Nielsen, Alex Avdeef

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 150 KB

english, 2004

45

PAMPA—a drug absorption in vitro model: 11. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates

Alex Avdeef, Per E Nielsen, Oksana Tsinman

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 264 KB

english, 2004

46

PAMPA—A drug absorption in vitro model: 13. Chemical selectivity due to membrane hydrogen bonding: In combo comparisons of HDM-, DOPC-, and DS-PAMPA models

Alex Avdeef, Oksana Tsinman

Journal:

European Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 310 KB

english, 2006

47

Permeation of permanently positive charged molecules through artificial membranes—Influence of physico-chemical properties

Holger Fischer, Manfred Kansy, Alex Avdeef, Frank Senner

Journal:

European Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 473 KB

english, 2007

48

Absorption-excipient-pH classification gradient maps: Sparingly soluble drugs and the pH partition hypothesis

Alex Avdeef, Manfred Kansy, Stefanie Bendels, Konstantin Tsinman

Journal:

European Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 1.45 MB

english, 2008

49

P-glycoprotein deficient mouse in situ blood–brain barrier permeability and its prediction using an in combo PAMPA model

Claude Dagenais, Alex Avdeef, Oksana Tsinman, Adam Dudley, Richard Beliveau

Journal:

European Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 1.06 MB

english, 2009

50

How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood–brain barrier permeability?

Journal:

European Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 1.52 MB

english, 2011

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